@Solarliner: Any official feedback so far?
It looks like someone is using it with O2016..
https://www.orbiter-forum.com/showthread.php?t=20&page=488
I can confirm it works with Orbiter 2016. You just need to download this ReShade version: http://www.mediafire.com/file/43ulu31ui431z43/ReShade+Framework+1.1.0.7z
Then follow the topic's instructions.
Note that you might have a runtime error. If this happened, you should reduce the rendering settings. You should enable D3D9 Anti Aliasing and reduce other settings such as anisotropic filtering.