Ok, so we have a go for Earth Aerospace industrial research.
I'll take over the initial location propagation and surface tiling, followed by location of transshipment bases. For added challenge we may want to create a "hub and spoke" system where smaller air transports, rail, and sealift assets move raw materials to a XR5-capable spaceport for mass haulage to a processing facility which may then send material out into space for final assembly. Priority will be given to existing spaceports such as SRC in Indonesia, Jarvis, Overton Island and WIN whose main purpose is to receive and send material to/from space as well as exchange resources suborbitally between themselves.
For short range hauling, DG-EX is capable of using existing, real world runways. Same goes for XR2 and DG-IV. As for slower modes of transportation (subsonic air freighters, ships, land transport, etc), this is not within the scope of Orbiter gameplay and can be simply roleplayed by positioning of static objects.
This might be more realistic and economically sound than flying in XR5s to every single factory or resource base location (we know how destructive those hover thrusters are). Furthermore STOVL mode on those spaceplanes require a lot of fuel and reduce the effective payload significantly. Whereas the DG-EX's much more efficient aerospike engines can cruise faster than any conventional aircraft today at a very high efficiency.