Definitely. Galileo's atmosphere probe, which entered Jupiter's atmosphere directly, suffered from 200 g of deceleration, which is clearly harmful, if not deadly, to humans if prolonged. Its heatshield lost over half its own weight (the heatshield itself made up half of the total probe's weight) during the entry.
The probe lost 1/4 of its weight just getting through the atmosphere. At least it managed to show we could do it. But after that, it also had to deal with pressure even before it stopped transmitting, and then the high temperature of the atmosphere itself.
Having said all this, what (crazed) space agency or (insane) astronaut would want to go to Jupiter directly? No one, to my knowledge, though the smaller moons are much more hospitable.
Now, it might just be possible to "land" on Jupiter without giving you spacecraft a serious weight-loss diet in the progress. It comes down to how you enter the atmosphere, which can be done directly or from orbit.
The Galileo probe did it directly, so it had a lot of speed relative to Jupiter. It's best to enter a orbit first, then drop the reentry vehicle, which should dramatically reduce the entry speeds and thus thermal protection mass. Even so, I doubt PICA would cut for the job. Perhaps a inflatable heatshield would be better? :idk:
EDIT: Urwumpe just :ninja:ed me...