I downloaded the big PDF and have just barely skimmed through it very quickly. A few things struck me on this first, very shallow exposure to the document:
1. Despite all the carping I do about NASA, the organization does have a LOT of smart, talented people in it.
2. But they have blinders on: The whole document seems to have been constructed in a sealed environment -- there's almost no reference to the social and political context of what they want to do other than a brief section of "justifications" that just rehashes the same stuff they've been trying to base their missions on since Apollo -- and which clearly isn't sufficient to get the kind of funding and political and social support they'd need to do even a small fraction of what's described.
3. The plans are all based on expendable space access, which is a no-starter, as far as I'm concerned.
4. Most of the work seems to have been done before Constellation was locked in; and the choices that locked in Constellation are inconsistent with a whole lot of what's described in the document.
5. Which makes it yet one more well-crafted fantasy from NASA.
But there is a lot of really good technical information in the document. Thanks for the pointer!