That's the interesting thing about flight simulators. I have done a lot of interesting things in X-Plane and Microsoft Flight Simulator too. But I doubt it can be done the same way in reality. Those airliners are not responsive and robust like smaller airplanes. At high speed regime of flight they are, but they also become more fragile for certain maneuvers.
In case a loop would be possible with a 747 mathematically, I think nobody would be willing to try it. Not Boeing, and not the most experienced test pilots