The picture above shows an interesting concept of a 'lateral centrifuge' spaceship. This ship rotates around the x-axis (as shown in the picture). The engines are located at -x, the crew is at +z and the reactor at -z. This arrangement gives a good separation of the reactor and crew, and a long baseline (d=125 m) for the centrifuge.
The disadvantage is that it can only be used for low-thrust engines, as the thrust leads to a bending stress in the mast stucture. This is why it has a lot of sailing-ship-like stays and spars, to strenghten the structure with least weight penalty.
The idea is to send it up in one piece, with self-deploying masts and an inflatable transhab. It would be part of a dual mission, as the lander would go separately on a cargo flight.
This design reminds me of Stuhlinger "Ion ships to Mars". Compared to a 'tomahawk' (or 'tumbling pigeon' design, as the Atomic rocket site calls it
) it retains the long centrifuge baseline of the whole ships length with the possibility to have continous thrust.
I think the design would be suitable for an ion or weak VASIMR drive. A slight disadvantage is that the floor of the centrifuged compartment will feel slightly inclined (front higher than rear), like on an airliner of today flying in a slightly nose-high attitude.
The main engines should be somewhat tiltable to allow controlling the rotation with the main engines, not only with the RCS system.
Before docking to the lander the rotation has to be stopped, but this would only be for a few days in Mars orbit, when preparing the descent to the surface.
Note: There is a NASA-paper on this design called "Preliminary Assessment of Artificial Gravity Impacts to Deep-Space Vehicle Design" by a guy called Kent Joosten.