NASA losing the shuttle does bite. But, it never became the cheap and reusable spacecraft that it was envisioned to be. Very manpower intensive and expensive, like it or not, it's soon to be gone. I'm sure some voters will show their frustrations in the voting booth. NASA brass has said it wouldn't be difficult to provide a few extra shuttle flights, but the program is moving to its end.
NASA can still access the ISS by way of the Soyuz, nothing wrong with it, it's proven, it's reliable and it was just used to put 3 members on site to the ISS yesterday.
SpaceX has won the contract to resupply the ISS, via it's soon to be tested Falcon9 rocket with the (reusable) Dragon capsule. Testing is underway now (
www.spacex.com), first flight of the Falcon/Dragon should be in May (fingers crossed). This would put SpaceX in good position to man-rate the Dragon for PAX (personnel) transfers, but that is still years away in any realistic view.
Last I read Bigelow Aerospace still has plans for an Orion Lite version to access their own plans for a commercial space station (read up on Genesis I and II), results have been pretty cool.
The DreamChaser, in the Orbiter world it looks like an HL-20, I'm sure it'll be available as a download soon (if it isn't already). Dreamchaser is to be built (perhaps) by Sierra Nevada, or Bensen Space Co. or somebody, who knows... It's a little hard to chase down, which means, it might never fly... Perhaps a later version might though.
Virgin Galactic and VSS Enterprise is probably going to be a leader in space tourism with a straight up/straight down space experience. No ability to go for an extended LEO for now.
To me, a dumb-ol' wrench turner, it looks like SpaceX is well positioned to lead the commercial space race, followed (chased?) by Bigelow. Elon Musk doesn't have shareholders to worry about, just contractual obligations. He's also expressed a desire to go to Mars, if I had the right background I'd be pounding on the door to sign up.
I almost forgot ESA's capabilities, their Jules Verne ATV is pretty sweet, get that man capable and it'll provide another method of getting crew to the ISS.
We are far from done with the ISS, NASA will more than likely be able to concentrate on the science of space. Unless there are some unforseen (or secret) things yet to happen, the flag-waving Nationalistic space program is probably over with (China notwithstanding). Future manned exploration will probably be multinational in order to share the costs.
I really hope I missed something, mankind is destined to explore, and no matter how much we spend "here at home" we will NEVER solve all the worlds problems.
...On an unrelated note, how's you station building project? I'm about a week away from the next base building launch...