I've been able to do P22 some times after studying the maps carefully. The terrain and textures in Orbiter 2016 are pretty impressive. But other times I have just not been able to do find the landmarks. So I'd answer your question with a careful maybe. :lol:
The idea behind those P22s was getting better coordinates of future landing sites and to get a better position of the landed LM. They were not crucial for the rest of the mission. Collins never managed to track Eagle on the surface, nor were all of his landmark trackings good enough to extract a more precise landmark position from them. As we all know, 11 got back to earth despite all that, so: yes, you can go ahead with the mission without the P22s.