My pursuit of this question: After using eyeballed spreadsheets for some years and getting tired of all the manual steps and text editing of .scn files to prepare a mission, I made a webbased XR mission planner, which allows the user to set all XR specific settings and create a flight plan, optionally based on results of the NASA Trajectory Browser (using web scraping as there is no API, but there's a lot more information in the html source of NASA's pages than the UI shows including state vectors and the MJD's of each step of the mission).
And it includes the Asterank browser to provide a gameplay element expressed in dollars. You can search for a big$$$$$ asteroid, then check if NASA has prepared a trajectory for this asteroid and if so, select your XR vessel, add payload and select a mission type.
So it became a mashup application. It allows the user to vary all config and re-run the rocket-equation on each change and see what the implications are. Once all the boxes for fuel and lox tick green, you can download the scenario at every step of the mission including associated files and install it as any add-on by unzipping the download in Orbiter's root folder.
Unfortunately, as a self-taught developer the project wasn't bug free to begin with. I would have shared it earlier if it was ready. And then Google changed the environment where it is running (Google Apps Script). That introduced more hassles. I need to fix things to get it running properly again. But I like to show this vid showing some of the features: